It gets me upset in the newspaper (4)
I believe the answer is:
item
'the newspaper' is the definition.
The definition and answer can be both man-made objects as well as being singular nouns.
Perhaps there's a link between them I don't understand?
'it gets me upset' is the wordplay.
'gets' means one lot of letters go next to another.
'upset' says the letters should be written backwards.
'me' in reverse letter order is 'em'.
'it'+'em'='ITEM'
'in' acts as a link.
Can you help me to learn more?
(Other definitions for item that I've seen before include "section of magazine" , "'One thing, poor mite (4)'" , "story" , "Two people considered together (informal)" , "See couple" .)