It may be detected in your eyes (5)
I believe the answer is:
smoke
'it may be detected in your eyes' is the definition.
The definition suggests a singular noun which matches the answer.
This is all the clue.
Can you help me to learn more?
(Other definitions for smoke that I've seen before include "Fumigate; cigarette" , "'There's no . . . . . without fire'" , "Cigarette or cigar (colloq.)" , "Use a cigarette" , "Fume" .)