It means one is apart, somehow (10)
I believe the answer is:
separation
'it' is the definition.
The definition suggests a singular noun which matches the answer.
'one is apart somehow' is the wordplay.
'somehow' indicates anagramming the letters.
'one'+'is'+'apart'='oneisapart'
'oneisapart' is an anagram of 'SEPARATION'.
'means' is the link.
Can you help me to learn more?
(Other definitions for separation that I've seen before include "Split" , "Detachment" , "Break-up" , "Disunion" , "divorce" .)