It must mean something when you find me again upset about a blockhead! (6)
I believe the answer is:
emblem
'it must mean something when you' is the definition.
The definition suggests a singular noun which matches the answer.
'find me again upset about a blockhead' is the wordplay.
'find' is an anagram indicator.
'again upset' becomes 'lem' (I am not sure about this - if you are sure you should believe this answer much more).
'about' is a charade indicator (letters next to each other).
'a blockhead' becomes 'b' (head letter of 'block').
'me' with letters rearranged gives 'em'.
'lem' after 'b' is 'blem'.
'em'+'blem'='EMBLEM'
Can you help me to learn more?
(Other definitions for emblem that I've seen before include "Symbolic representation on badge etc" , "Crest or insignia" , "Symbol; heraldic device" , "Mark" , "Symbolic object" .)