It tastes hot and makes many unwell (4)
I believe the answer is:
dill
'it tastes hot and' is the definition.
The definition suggests a singular noun which matches the answer.
'many unwell' is the wordplay.
'many' becomes 'd' ().
'unwell' becomes 'i'll' (similar in meaning).
'd'+'ill'='DILL'
'makes' acts as a link.
Can you help me to learn more?
(Other definitions for dill that I've seen before include "Herb of parsley family" , "Pickling herb" , "Culinary herb" , "Herb; rhymes with beak" , "Herb for gravadlax" .)