Italian article accepted by Red Cross (5)
I believe the answer is:
riled
'cross' is the definition.
(I've seen this in another clue)
'italian article accepted by red' is the wordplay.
'italian article' becomes 'il' (the definite article in Italian).
'accepted by' is an insertion indicator (inserted letters are accepted).
'il' going inside 'red' is 'RILED'.
(Other definitions for riled that I've seen before include "Cross" , "get angry" , "Nettled" , "Annoyed" , "Made angry" .)