Italian brother - far out! (3)
I believe the answer is:
fra
'italian brother' is the definition.
(I've seen this in another clue)
'far out' is the wordplay.
'out' is an anagram indicator (out can mean wrong or inaccurate).
'far' is an anagram of 'FRA'.
(Other definitions for fra that I've seen before include "Italian monk" , "Brother (Italian)" , "Italian monk's title" .)