Italian food unknown in the middle of Tuscany only (7)
I believe the answer is:
calzone
'italian food' is the definition.
(type of pizza)
'unknown in the middle of tuscany only' is the wordplay.
'unknown' becomes 'z' (algebra).
'in the' indicates putting letters inside.
'middle of' says to take the centre.
'only' becomes 'alone' (synonyms).
The middle of 'tuscany' is 'c'.
'c'+'alone'='calone'
'z' inserted inside 'calone' is 'CALZONE'.
(Other definitions for calzone that I've seen before include "Type of pizza - clean Oz (anag)" , "food in Venice?" , "Folded type of pizza" , "Pizza dough turnover" , "Folded variety of pizza" .)