Italian region may be twinned with cold English county (6)
I believe the answer is:
umbria
'italian region' is the definition.
(Umbria is an example)
I cannot understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for umbria that I've seen before include "in the Tiber region" , "Mountainous region in central Italy" , "part of Italy" , "Italian region" , "hilly area of Italy" .)