It's a river, lady, and a great big one! (6)
I believe the answer is:
amazon
'it's a river' is the definition.
(Amazon is an example)
I cannot understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for amazon that I've seen before include "Mighty river of S America, or tough woman" , "big river" , "Mythic woman warrior" , "Strong, well-built woman" , "banker" .)