It's different, being under informal head? Not something to worry about! (2,6)
I believe the answer is:
no bother
'not something to worry about' is the definition.
I know nothing about this answer so I cannot tell whether this works.
'it's different being under informal head?' is the wordplay.
'it's different' becomes 'other' (similar in meaning).
'being under' is a charade indicator (letters next to each other) (in a down clue, some letters go below others).
'informal head?' becomes 'nob' (I've seen this in other clues. I am not sure about the 'informal' bit.).
'other' put after 'nob' is 'NO BOTHER'.
Can you help me to learn more?
I've seen this clue in The Times.
Want a hint initially instead of a full solution?
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