It's different in Motherwell (5)
I believe the answer is:
other
'it's different' is the definition.
(similar in meaning)
'in motherwell' is the wordplay.
'in' indicates a hidden word.
'OTHER' is hidden within 'motherwell'.
(Other definitions for other that I've seen before include "Different, not the same one or this one" , "One may be significant" , "Alternative - unrelated" , "Different, alternative" , "Alternate; additional" .)