It's harsh for new family in the centre of Bude (6)
I believe the answer is:
unkind
'it's harsh' is the definition.
('unkind' can be a synonym of 'harsh')
'new family in the centre of bude' is the wordplay.
'new' becomes 'n'.
'family' becomes 'kin' ('kin' can be a synonym of 'family').
'in the' is an insertion indicator.
'centre of' says to take the centre.
The middle of 'bude' is 'ud'.
'n'+'kin'='nkin'
'nkin' placed within 'ud' is 'UNKIND'.
'for' acts as a link.
(Other definitions for unkind that I've seen before include "Harsh, pitiless" , "Uncaring, nasty" , "Mean, pitiless" , "Heartless, brutal" , "Thoughtless -- inhumane" .)