Its irritating getting on them (6)
I believe the answer is:
nerves
If this is the answer I cannot explain how the clue works.
Can you help me to learn more?
(Other definitions for nerves that I've seen before include "Bodily fibres carrying impulses of sensation" , "Bodily fibres that convey sensations" , "Bodily fibres conveying sensations" , "causing some anxiety" , "Bundles of fibres in the body" .)