It's linked with a certain reaction (5)
I believe the answer is:
chain
'reaction' is the definition.
(chain reaction is a kind of reaction)
I cannot understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for chain that I've seen before include "Event series" , "Series of connected links" , "Shackle" , "group of shops here" , "Paper decoration" .)