Its mouth may be full of fish (5)
I believe the answer is:
river
'fish' is the definition.
Although both the answer and definition are singular nouns, I can't see how they can define each other.
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for river that I've seen before include "Flowing water" , "Exe, Po" , "Current" , "course of 1d [ADVENTURE]" , "Large flow of liquid" .)