It's negative, out of the way, and unpleasant (5)
I believe the answer is:
nasty
'unpleasant' is the definition.
(synonyms)
'it's negative out of the way' is the wordplay.
'it's negative' becomes 'nay' (nay is a kind of negative).
'out of' is an insertion indicator.
'the way' becomes 'st'.
'nay' enclosing 'st' is 'NASTY'.
'and' is the link.
(Other definitions for nasty that I've seen before include "Horrible" , "Mean" , "Offensive or malicious" , "Evil" , "Horrid, repugnant" .)