It's no good being practically penniless (4)
I believe the answer is:
poor
'penniless' is the definition.
(similar in meaning)
'it's no good being practically' is the wordplay.
I cannot really see how this works, but
'no' could be 'o' (resembles 0 - 'no' can mean 'zero') and 'o' is located in the answer.
The remaining letters 'por' is a valid word which might be clued in a way I don't see.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for poor that I've seen before include "Of inferior quality or means" , "Without means" , "Inadequate" , "Hard up" , "Mere" .)