It's on fire over in Antilles (3)
I believe the answer is:
lit
'it's on fire' is the definition.
(I've seen this in another clue)
'over in antilles' is the wordplay.
'over' is a reversal indicator.
'in' indicates a hidden word.
'til' is hidden in the letters of 'antilles'.
'til' written backwards gives 'LIT'.
(Other definitions for lit that I've seen before include "landed here" , "fine writing in condensed form" , "Enlightened" , "Burning" , "Set afire" .)