It's played to annoy Luddite on vacation (5)
I believe the answer is:
bugle
'it's played' is the definition.
(musical instrument)
'annoy luddite on vacation' is the wordplay.
'annoy' becomes 'bug' (I've seen this in another clue).
'on vacation' says to hollow out the word (remove centre letters) (after the inside letters have vacated the word).
'luddite' with its centre taken out is 'le'.
'bug'+'le'='BUGLE'
'to' acts as a link.
(Other definitions for bugle that I've seen before include "Bit of brass" , "one may have blown it!" , "costume ornament?" , "Mil. trumpet" , "Small trumpet; plant" .)