It's played with effortless artistry (5)
I believe the answer is:
sitar
This could be a double definition.
'it's played' is the first definition.
(sitar is a kind of musical instrument)
'effortless artistry' is the second definition.
Although both the answer and definition are singular nouns, I don't see how they can define each other.
'with' acts as a link.
Can you help me to learn more?
(Other definitions for sitar that I've seen before include "Guitar-like instrument" , "Indian string instrument" , "Lasting from morning to night" , "instrument out east" , "music producer" .)