It's the end of the road, stranger, when you shake so! (6)
I believe the answer is:
dodder
'you shake so' is the definition.
I can't judge whether this defines the answer.
'it's the end of the road stranger' is the wordplay.
'it's the end of the' indicates one should take the final letters.
'stranger' becomes 'odder' (more odd).
The last letter of 'road' is 'd'.
'd'+'odder'='DODDER'
'when' acts as a link.
Can you help me to learn more?
(Other definitions for dodder that I've seen before include "Walk unsteadily along the Dublin river?" , "go falteringly" , "Be decrepit in the Dublin river" , "Be slow and unsteady" , "Totter into the Dublin river" .)