It's true about leaders in Little Italy put away to make things possible (10)
I believe the answer is:
facilitate
'make things possible' is the definition.
'facilitate' can be an answer for 'make' (thesaurus). I am not sure about the 'things possible' bit.
'it's true about leaders in little italy put away' is the subsidiary indication.
'it's true' becomes 'fact' (I've seen this before).
'about' indicates putting letters inside.
'leaders in little' becomes 'il' (I can't justify this - if you can you should give a lot more credence to this answer).
'italy' becomes 'i'.
'put away' becomes 'ate' (I've seen this in other clues).
'il'+'i'='ili'
'fact' going around 'ili' is 'facilit'.
'facilit'+'ate'='facilitate'
'to' is the link.
Can you help me to learn more?
(Other definitions for facilitate that I've seen before include "Ease" , "Make (something) easy" , "Make easier" .)