Jacqueline du Pré's instrument (5)
I believe the answer is:
cello
'jacqueline du pre's instrument' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for cello that I've seen before include "Large stringed instrument" , "It's bigger than a viola, but smaller than a double bass" , "Instrument in the violin family" , "Musical instrument like large violin held between knees" , "String quartet instrument" .)