Jo prayed about hazard (8)
I believe the answer is:
jeopardy
'hazard' is the definition.
('jeopardy' can be a synonym of 'hazard')
'jo prayed about' is the wordplay.
'about' indicates anagramming the letters.
'jo'+'prayed'='joprayed'
'joprayed' is an anagram of 'JEOPARDY'.
(Other definitions for jeopardy that I've seen before include "Hazard, risk" , "Danger of injury, loss, death, etc" , "Peril. danger" , "Danger of harm" , "See 15" .)