Job anxiety leads to early retirement (6)
I believe the answer is:
career
'job' is the definition.
(thesaurus)
'anxiety leads to early retirement' is the wordplay.
'anxiety' becomes 'care' (care is a kind of anxiety).
'leads to' says to take the initial letters.
The first letters of 'early retirement' is 'er'.
'care'+'er'='CAREER'
(Other definitions for career that I've seen before include "race" , "Move swiftly" , "Life's work path" , "go very fast" , "Job (supposedly for life?)" .)