Jobs -- first in there enquires (5)
I believe the answer is:
tasks
'jobs' is the definition.
('task' can be a synonym of 'job')
'first in there enquires' is the wordplay.
'first in' suggests taking the first letters.
'enquires' becomes 'asks' ('ask' can be a synonym of 'enquire').
The initial letter of 'there' is 't'.
't'+'asks'='TASKS'
(Other definitions for tasks that I've seen before include "charges" , "Assignments" , "Labours" , "Pieces of work" , "'Jobs, undertakings (5)'" .)