Joint inflammation (4)
I believe the answer is:
gout
'joint inflammation' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for gout that I've seen before include "Toe-swelling disease" , "Complaint" , "Disease causing inflammation, often of foot or toes" , "Toe-inflammation disease" , "Painful disease of feet" .)