Joint trouble rising, pinching limb's edges (5)
I believe the answer is:
elbow
'joint' is the definition.
(elbow is a kind of joint)
'trouble rising pinching limb's edges' is the wordplay.
'trouble' becomes 'woe' (I've seen this before).
'rising' is a reversal indicator (going up in a down clue).
'pinching' indicates putting letters inside (taking inside).
'edges' says to hollow out the word (remove centre letters) (I've seen 'edges of' mean this).
'limb' with its middle taken out is 'lb'.
'woe' reversed gives 'eow'.
'eow' enclosing 'lb' is 'ELBOW'.
(Other definitions for elbow that I've seen before include "Jostle" , "given to one about to leave" , "Arm joint, more power to it" , "Sort of grease" , "part of the body" .)