Keep quiet over substitute (8)
I believe the answer is:
preserve
'keep' is the definition.
(I know that keep can be written as preserve)
'quiet over substitute' is the wordplay.
'quiet over' becomes 'p' (I can't justify this - if you can you should believe this answer much more).
'substitute' becomes 'reserve' (synonyms).
'p'+'reserve'='PRESERVE'
Can you help me to learn more?
(Other definitions for preserve that I've seen before include "put on the table in advance?" , "defend" , "Keep alive, maintain" , "Particular interest" , "Eg, jam" .)