Keep the Italian away from Estoril somehow! (5)
I believe the answer is:
store
'keep' is the definition.
(I know that store is a more specific form of keep)
'the italian away from estoril somehow' is the wordplay.
'the italian' becomes 'il' (Italian for 'the').
'away from' indicates named letters should be taken away.
'somehow' is an anagram indicator.
'estoril' with 'il' taken out is 'estor'.
'estor' is an anagram of 'STORE'.
(Other definitions for store that I've seen before include "Depository for goods" , "Supermarket" , "Large shop; computer memory" , "Shop; hoard" , "Large shop; keep" .)