Key alien's set free (9)
I believe the answer is:
essential
'key' is the definition.
(thesaurus)
'alien's set free' is the wordplay.
'free' is an anagram indicator.
'aliens'+'set'='aliensset'
'aliensset' with letters rearranged gives 'ESSENTIAL'.
(Other definitions for essential that I've seen before include "organic" , "Indispensible" , "Basic or necessary" , "Vitally important" , "Key" .)