Lack of mobility is first of troubles for Left in Spanish region (9)
I believe the answer is:
catatonia
'lack of mobility' is the definition.
(state of inertia or immobility)
'first of troubles for left in spanish region' is the wordplay.
I cannot quite see how this works, but
'first' could be 'i' (I in Roman numerals eg Elizabeth I) and 'i' is present in the answer.
'for' could be 'to' (eg both can mean 'in the opinion of') and 'to' is found in the answer.
This may be the basis of clue (or it may be nonsense).
'is' is the link.
(Other definitions for catatonia that I've seen before include "Lifeless" , "Unresponsiveness" , "State of immobility and stupor" , "unresponsive" , "State of muscular rigidity and stupor" .)