Lacking caution in endeavour — a shame (4)
I believe the answer is:
rash
'lacking caution' is the definition.
'in endeavour a shame' is the wordplay.
'in' says the answer is hidden in the clue.
'RASH' can be found hidden inside 'endeavour a shame'.
(Other definitions for rash that I've seen before include "Unwisely incurring danger" , "Foolhardy about the skin infection" , "Precipitate" , "Eruption of spots on skin" , "Lacking in caution" .)