Ladies' hard work, energy and time (6)
I believe the answer is:
toilet
'ladies'' is the definition.
(ladies toilet)
'hard work energy and time' is the wordplay.
'hard work' becomes 'toil' (I've seen this in another clue).
'energy' becomes 'e' (physics symbol as in E=mco).
'and' is a charade indicator (letters next to each other).
'time' becomes 't' (abbreviation).
'toil'+'e'+'t'='TOILET'
(Other definitions for toilet that I've seen before include "It means washing" , "Smallest room" , "something to go on?" , "Lavatory paper" , "WC" .)