Lady's worried about office not working properly (13)
I believe the answer is:
dysfunctional
'not working properly' is the definition.
(I've seen this before)
'lady's worried about office' is the wordplay.
'worried' indicates anagramming the letters (worry can mean to interfere with or disturb).
'about' means one lot of letters goes inside another.
'office' becomes 'function' (synonyms).
'ladys' anagrammed gives 'dysal'.
'dysal' placed around 'function' is 'DYSFUNCTIONAL'.
(Other definitions for dysfunctional that I've seen before include "Operating with impairment" , "Not operating properly" , "Socially incapable and abnormal" , "Maladjusted" , "Not operating normally" .)