Lament funny Beano comic's central character (6)
I believe the answer is:
bemoan
'lament' is the definition.
(synonyms)
'funny beano comic's central character' is the wordplay.
'funny' indicates anagramming the letters.
'central character' means to look at the middle letters.
The middle of 'comic' is 'm'.
'beano'+'m'='beanom'
'beanom' with letters rearranged gives 'BEMOAN'.
(Other definitions for bemoan that I've seen before include "Complain about, lament" , "Lament, grieve" , "Deplore, lament" , "Regret, lament" .)