Large dress designed anyhow (10)
I believe the answer is:
regardless
'anyhow' is the definition.
(thesaurus)
'large dress designed' is the wordplay.
'designed' is an anagram indicator (designed with the letters).
'large'+'dress'='largedress'
'largedress' anagrammed gives 'REGARDLESS'.
(Other definitions for regardless that I've seen before include "Despite the prevailing circumstances" , "in any case" , "in spite of everything" , "Anyway" , "CARRY ON FILM" .)