Large groups from Rhodes (6)
I believe the answer is:
hordes
'large groups' is the definition.
(I've seen this in another clue)
'from rhodes' is the wordplay.
'from' is an anagram indicator (the anagram comes from the same letters).
'rhodes' with letters rearranged gives 'HORDES'.
(Other definitions for hordes that I've seen before include "Horsed around with the multitudes" , "Huge noisy crowds" , "large numbers" , "Many" , "Vast multitudes" .)