Large home with study and tree (6)
I believe the answer is:
linden
'tree' is the definition.
(linden tree is a kind of tree)
'large home with study' is the wordplay.
'large' becomes 'l'.
'home' becomes 'in' ('he's home' can mean 'he's in').
'with' says to put letters next to each other.
'study' becomes 'den' (term for a study or office).
'l'+'in'+'den'='LINDEN'
'and' is the link.
(Other definitions for linden that I've seen before include "Tree with Lea - also called 8" , "Unter den ------, iconic boulevard in Berlin" , "Lime tree" , "One twigged" , "type of tree" .)