Large Italian male is agile (5)
I believe the answer is:
lithe
'agile' is the definition.
(I've seen this in another clue)
'large italian male' is the wordplay.
'large' becomes 'L' (eg in clothes sizes).
'italian' becomes 'it' (abbreviation for Italian).
'male' becomes 'he' (he refers to a man).
'l'+'it'+'he'='LITHE'
'is' acts as a link.
(Other definitions for lithe that I've seen before include "Not inflexible" , "Physically flexible or supple" , "Loose-limbed" , "quick to move" , "Able to move and bend gracefully" .)