Large part of skeleton (6)
I believe the answer is:
pelvis
'large part of skeleton' is the definition.
(I've seen this before)
This is the entire clue.
(Other definitions for pelvis that I've seen before include "Large part of skeleton" , "Large bony frame" , "Bony structure at the base of the spine" , "Hip structure" , "It supports the lower limbs" .)