Large snake’s means of climbing (6)
I believe the answer is:
ladder
'means of climbing' is the definition.
'ladder' can be an answer for 'means' (I have seen 'Means of ascent' mean 'ladder' so perhaps 'means' could also mean 'ladder'). I'm not certain of the 'of climbing' bit.
'large snake's' is the wordplay.
'large' becomes 'L' (eg in clothes sizes).
'snake' becomes 'adder' (adder is a kind of snake).
'l'+'adder'='LADDER'
Can you help me to learn more?
(Other definitions for ladder that I've seen before include "Household climbing device or hole in stocking" , "A fire-fighter may use one" , "Row of unravelled stitches" , "1 [UNLUCKY FOR SOME]" , "Vertical run in tights" .)