Largest of Canada's First Nations (4)
I believe the answer is:
cree
'largest of canada's first nations' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for cree that I've seen before include "Member of an Algonquian people of central Canada" , "Soften up" , "Native American tribe/language" , "Native American; rhymes with French cheese" , "tribesman" .)