Lass biting Chuck in comprehensive (6)
I believe the answer is:
global
'comprehensive' is the definition.
(similar in meaning)
'lass biting chuck' is the wordplay.
'lass' becomes 'gal' (both can mean a girl).
'biting' indicates putting letters inside (some letters bite or swallow others).
'chuck' becomes 'lob' (I've seen this before).
'gal' enclosing 'lob' is 'GLOBAL'.
'in' acts as a link.
(Other definitions for global that I've seen before include "blanket" , "Across our planet" , "All-encompassing" , "Like big village" , "Of the whole world, worldwide" .)