Last change includes new inclination (5)
I believe the answer is:
slant
'inclination' is the definition.
(slant is a kind of inclination)
'last change includes new' is the wordplay.
'change' is an anagram indicator.
'includes' is an insertion indicator.
'new' becomes 'n'.
'last' with letters rearranged gives 'slat'.
'slat' going around 'n' is 'SLANT'.
(Other definitions for slant that I've seen before include "Chance" , "Inclination" , "Lean, point of view" , "Angle; make oblique" , "Angle; incline" .)