Last female in a league (5)
I believe the answer is:
final
'last' is the definition.
(synonyms)
'female in a league' is the wordplay.
'female' becomes 'f' (abbreviation).
'league' becomes 'l' (abbreviation).
'f'+'in'+'a'+'l'='FINAL'
(Other definitions for final that I've seen before include "big match" , "Not to be altered" , "Conclusive" , "Last in a series of games or contests" , "Like one's journey to cemetery" .)