Last in spite of everything (5,3)
I believe the answer is:
after all
I believe this clue is a double definition.
'last' is the first definition.
(coming after everyone else)
'in spite of everything' is the second definition.
(I've seen this in another clue)
(Other definitions for after all that I've seen before include "In spite of any indications to the contrary" , "Where most dictionary entries are" , "Bringing up the rear" , "despite great effort" , "Taking everything into account" .)