Last of dead nettle one could be stuck with (4)
I believe the answer is:
dirk
'one could be stuck with' is the definition.
(type of dagger)
'last of dead nettle' is the wordplay.
'last of' indicates one should take the final letters.
'nettle' becomes 'irk' (both can mean to irritate**).
The last letter of 'dead' is 'd'.
'd'+'irk'='DIRK'
(Other definitions for dirk that I've seen before include "which might get one stuck in Highlands" , "Dagger (belonging to Bogarde?)" , "Type of dagger" , "Highland dagger" , "Small dagger" .)