Last of many people from the east and one from Aden (6)
I believe the answer is:
yemeni
'aden' is the definition.
Both the answer and definition are singular nouns.
Maybe you can see an association between them that I can't see?
'last of many people from the east and one' is the wordplay.
'last of' suggests the final letters.
'the east' becomes 'E' (abbreviation).
'and' becomes 'n' (common abbreviation for 'and').
'one' becomes 'i' (Roman numeral).
The final letters of 'many people from' are 'yem'.
'yem'+'e'+'n'+'i'='YEMENI'
'from' is the link.
Can you help me to learn more?
(Other definitions for yemeni that I've seen before include "Native of Sana'a, say" , "Someone from Aden?" , "language" , "from the Middle East" , "Person from Sana'a, say" .)